Lewis and Clark High School is a four-year public secondary school in Spokane, Washington, United States. Opened in 1912, it is located at 521 W. Fourth Ave. in the Cliff/Cannon neighborhood of downtown Spokane, bounded by I-90 to the north and MultiCare Deaconess Hospital to the west. It replaced South Central High School, destroyed by fire in 1910, and was named for the two leaders of the Corps of Discovery.