Madonna Catholic Secondary School

Madonna Catholic Secondary School (MCSS), formerly known as Madonna High School is an all-girls Catholic secondary school located in Toronto, Ontario, Canada administered by the Toronto Catholic District School Board (formerly the Metropolitan Separate School Board). The school was founded in 1963 by the Faithful Companions of Jesus and became a member of the MSSB family of schools in 1986.

The school is one of six all-female Catholic high schools in the district and 31 in the TCDSB. Madonna is ranked 516 in the 2017–18 Fraser Institute Report Card.

Madonna is a sister school to Chaminade College School and sports rival to Loretto Abbey Catholic Secondary School.