Nazareth Regional High School is a four-year private, Roman Catholic, college preparatory high school in Brooklyn, New York. It is located within the Roman Catholic Diocese of Brooklyn.

It is a multiethnic, multi-religious, coeducational school that offers a four-year academic, college preparatory and religious education curriculum. It is governed by a policy-making lay board of trustees and affiliated with the American Central Province of the Xaverian Brothers. It is chartered by the Board of Regents of the University of the State of New York, and accredited by the Middle States Association of Colleges and SchoolIteol serves approximately 400 students from the New York metropolitan area.