Oak Park High School is a public high school located in Oak Park, Michigan, United States, an inner suburb of Detroit. The school is part of the Oak Park School district. It serves about 1,130 students in grades 9 to 12 from Oak Park and surrounding communities around Detroit.

In 2010, as a part of the Federal School Improvement Framework, the school was identified by the State of Michigan as one of 92 schools with the lowest achieving, according to performance on Michigan standardized tests. Eligible schools were invited to apply for a grant of up to $6 million over three years to support efforts to raise academic achievement.

Oak Park High School's grant application was awarded $4.2 million. The school was one of 28 schools that were awarded grant funds.

The school colors are red, black, and white. The school mascot is the Oak Park Knights.