Sir Frederick Banting Secondary School is a high school located in London, Ontario, Canada. It is part of the Thames Valley District School Board. The school is named after Sir Frederick Banting, who won the Nobel Prize for the discovery of insulin in 1923. The school was officially opened in 1969 with Lady Banting, widow of Sir Frederick Banting, in attendance. The founding principal (1968–1970) was George A. Robbins. Banting is recognized for having a strong French Immersion program and a music program.

Currently 1,893 students from grade 9–12 are enrolled.

Irene Mathyssen, the former Member of Parliament for London-Fanshawe, taught English at the school until she was elected in the 2006 federal election.

Banting shares an almost exact floor plan with its sister school, Montcalm Secondary School.

The school participated in CBC's series The Greatest Canadian, in which Sir Frederick Banting was nominated.