The State University of New York at Buffalo (commonly referred to as University at Buffalo, UB, or sometimes SUNY Buffalo) is a public research university in Buffalo and Amherst, New York, United States. The university was founded in 1846 as a private medical college and merged with the State University of New York system in 1962. It is one of two flagship institutions of the SUNY system, along with Stony Brook University. As of fall 2023, the university enrolled nearly 32,000 students in 13 schools and colleges, making it the largest public university in the state of New York.

Since its founding by a group which included future United States president Millard Fillmore, the university has evolved from a small medical school to a research university. Today, in addition to the College of Arts and Sciences, the university houses the largest state-operated medical school, dental school, education school, business school, engineering school, and pharmacy school, and is also home to SUNY's only law school. UB has the largest endowment and most research funding among the universities in the SUNY system. The university offers bachelor's degrees in over 140 areas of study, as well as over 220 master's programs and over 95 doctoral programs, and 55 combined degree programs. The University at Buffalo is one of two universities founded by United States Presidents.

The University at Buffalo is classified among "R1: Doctoral Universities – Very high research activity". In 1989, UB was elected to the Association of American Universities. The University at Buffalo intercollegiate athletic teams are the Bulls. They compete in Division I of the NCAA and are members of the Mid-American Conference.