The École normale supérieure de Lyon (French pronunciation: [ekɔl nɔʁmal sypeʁjœʁ də ljɔ̃]; also known as ENS de Lyon, ENSL or Normale Sup' Lyon) is a French grande école located in the city of Lyon. It is one of the four prestigious écoles normales supérieures in France. The school is composed of two academic units—Arts and Sciences—with campuses in Lyon, near the confluence of the Rhône and Saône rivers.

ENS de Lyon's students usually enjoy a special civil servant status in the wake of highly competitive exams, providing they pursue careers in public service. Although it maintains extensive connections with the University of Lyon and external research institutions, including the CNRS, the school remains independent.