ESPCI Paris (officially the École supérieure de physique et de chimie industrielles de la ville de Paris, pronounced [ekɔl sypeʁjœʁ də fizik e də ʃimi ɛ̃dystʁijɛl də la vil də paʁi], "The City of Paris Industrial Physics and Chemistry Higher Educational Institution") is a grande école founded in 1882 by the city of Paris, France. It educates undergraduate and graduate students in physics, chemistry and biology and conducts high-level research in those fields. It is ranked as the first French École d'Ingénieurs in the 2017 Shanghai Ranking.

ESPCI Paris is a constituent college of Université PSL and a founding member of the ParisTech (Paris Institute of Technology) alliance.

Two thirds of the students enter the school following a competitive examination (concours X-ESPCI-ENS) following at least two years of Classes Préparatoires. The other students are recruited by submitting applications. The school itself is also known as Physique-Chimie or simply PC.

ESPCI Paris nurtures relationships with many industrial partners such as Schlumberger, Rhodia, TotalEnergies, Thales, Arkema, Michelin, Withings, which sponsors groups of students and has research contracts with ESPCI laboratories. ESPCI Paris also has partnerships with L'Oréal and Saint-Gobain for professional recruitment.