Barnstable High School is a public high school (grades 8–12) in the village of Hyannis, Massachusetts, United States, Town of Barnstable. The school is part of the Barnstable Public School District.

Barnstable High School was founded in the 19th century and was located on High School Road in Hyannis before relocating to its current location on West Main Street in 1959. The school has had several major renovations and building additions over the years, most recently in 1998.