Brookline High School is a four-year public high school in Brookline, Massachusetts. It is a part of Public Schools of Brookline.

As of the 2023–24 school year, 2117 students were enrolled in the high school, served by 191.8 teachers (on an FTE basis), the student to teacher ratio was approximately 10.9 to 1. As of 2023, the enrolled student body race/ethnicity was self reported as 7.4% African American, 16.0% Asian, 12.9% Hispanic, 53.3% White, and 10.3% Multi-ethnic.