Grafton High School is a high school in Grafton, Massachusetts, United States. The school has an enrollment size of approximately 900 students in grades 9–12.

The curriculum offers a wide variety of courses in areas of business and computer science, music, video game design, English, family consumer science, health, physical education, mathematics, science and technology, social studies, special education, visual and performing arts, world languages, community service, school service, and independent studies.