Harry S. Truman High School is a public high school at 750 Baychester Avenue, in the Co-op City section of the Bronx, New York City, United States. The school is designated as an Empowerment School by the New York City Department of Education, which allows it more autonomy in choosing a curriculum. Truman shares a uniquely designed and interconnected campus with two middle schools, MS 180 and 181, and two elementary schools, PS 178 and 153. The campus was designed to be a one-stop and close-to-home solution for students and families in the Co-op City neighborhood, although many of the students commute to school from other parts of the city. The main Truman building is also home to the Bronx Health Sciences High School, which occupies a portion of the third floor, and PS 176X, a special education school for autistic students, which shares a small portion of the first and second floors.

Truman High School is one of the remaining large high schools in the Bronx that has not been phased out and broken up into a number of small schools. This trend, which has been popular in the city, has seen other high schools in the borough, such as Evander Childs High School and Roosevelt High School closed and split into a number of smaller schools located in the same building. The school does, however, host Bronx Health Sciences High School created as part of the small schools movement, and previously hosted two additional high schools which have since moved to other locations. Truman High School and Bronx Health Sciences compose Harry S. Truman Educational Campus.