Rye St Antony School was an independent Roman Catholic boarding and day school for girls aged 3 to 18 years and boys aged 3 to 11 years in Headington, Oxford, England. The school's name was commonly abbreviated and referred to by both pupils and staff as 'Rye'. Rye was unique as a girls' independent Catholic school due to the fact that it was founded by two women rather than by a religious order.

In 2024, it merged with Headington School to become a new school, named "Headington Rye Oxford".