Silliman College is a residential college at Yale University in New Haven, Connecticut. The college is named for Benjamin Silliman, the first science professor at Yale. It opened in September 1940 as the last of the original ten residential colleges, and contains buildings constructed as early as 1901.

Silliman is Yale's largest residential college by its footprint, occupying most of a city block. Due to its size, the college is able to house its first-year students in the college instead of on Yale's Old Campus. The college's architecture is varied: though architect Otto Eggers completed most of the college with Georgian buildings, the college also incorporates two early-20th century buildings in the French Renaissance and Gothic Revival styles.

The college has links to Harvard's Pforzheimer House and Dudley House, as well as Trinity College, Cambridge and Brasenose College, Oxford. Its rival college at Yale is Timothy Dwight College, located directly across Temple Street.