Valley Stream Central High School is a public senior high school (grades 10–12) in the Incorporated Village of Valley Stream in Nassau County, on the South Shore of Long Island, in New York, United States. It is part of the Valley Stream Central High School District. Candace Hugee has been the Principal since 2023. According to U.S. News & World Report, Central is the top performing High School in the District with the ranking of #103 in New York State compared to North's #138 and South's #131. Central has a graduation rate of above 95% and was recently recognized by New York State for having one of the highest graduation rates among men of color.

As of the 2022–23 school year, the school had an enrollment of 1,078 students and 78.6 classroom teachers (on an FTE basis), for a student–teacher ratio of 13.7:1. There were 420 students (39.0% of enrollment) eligible for free lunch and 43 (4.0% of students) eligible for reduced-cost lunch.