Wadham College ( WOD-əm) is a constituent college of the University of Oxford in the United Kingdom. It is located in the centre of Oxford, at the intersection of Broad Street and Parks Road. Wadham College was founded in 1610 by Dorothy Wadham, according to the will of her late husband Nicholas Wadham, a member of an ancient Devon and Somerset family.

The central buildings, a notable example of Jacobean architecture, were designed by the architect William Arnold and erected between 1610 and 1613. They include a large and ornate Hall. Adjacent to the central buildings are the Wadham Gardens. Wadham is one of the largest colleges of the University of Oxford, with about 480 undergraduates and 240 graduate students. The college publishes an annual magazine for alumni, the Wadham College Gazette. As of 2022, it had an estimated financial endowment of £113 million, and in the 2021–2022 academic year ranked seventh in the Norrington Table, a measure which ranks Oxford colleges by academic performance.

Amongst Wadham's most famous alumni is Sir Christopher Wren. Wren was one of a group of experimental scientists at Oxford in the 1650s, the Oxford Philosophical Club, which included Robert Boyle and Robert Hooke. This group held regular meetings at Wadham College under the guidance of the warden, John Wilkins, and the group formed the nucleus which went on to found the Royal Society.