Jefferson High School (JHS, formally Thomas Jefferson High School) is a public high school in Portland, Oregon, United States.

The school itself is a Middle College Program, having converted from being a comprehensive high school in 2011. Students enrolled at the school take classes at both it and the Cascade campus of Portland Community College, located across the street from the program. Eighth graders at Faubion, Harriet Tubman, Ockley Green, or Vernon middle schools are given the choice between it or their neighborhood high school (which is Grant, McDaniel, or Roosevelt high schools). Students living out of these boundaries can also attend, but within a lottery based application process.

Ninth graders given the enrollment choice are guaranteed to attend Jefferson. In eleventh grade, all students need to be evaluated by the principal.