La Salle Academy is an American private, Catholic all-boys' high school in the Manhattan borough of New York City, New York.

The school is run by the Eastern North American District of the Institute of the Brothers of the Christian Schools.

It was founded by the Christian Brothers in 1848.

The school was first named Saint Vincent's School when it opened on Canal Street. It moved to Second Avenue in 1856 and changed its name to La Salle Academy in 1887.

Between 2010 and 2025, the school relocated to 215 East 6th Street, sharing the building with St. George Academy. La Salle Academy moved back to its historic East 2nd Street location in September 2025.

Throughout its history, the school has been home to thousands of "Brothers' boys".