Pope Francis Preparatory School is a Catholic co-educational college-preparatory high school in Springfield, Massachusetts.

The school was originally opened as Cathedral High School in 1883 by the Sisters of Saint Joseph at St. Michael's Cathedral. In 2011, the school's building was destroyed by a tornado. A few years later in 2015, it was announced that it would merge with Holyoke Catholic High School in Chicopee to form a new regional Catholic school. The new building was completed in 2016 and reopened as Pope Francis High School. The school was later renamed to the current moniker. The school's current building is on the site of the original Cathedral High School.