The Spence School is an American all-girls private school in New York City, founded in 1892 by Clara B. Spence.

Spence has about 740 students, with grades K-4 representing the Lower School, 5-8 representing the Middle School, and 9-12 representing the Upper School. Lower school average class sizes are 16-18 and middle and upper school average class sizes are 13–14. The student: teacher ratio is 7:1 and students of color in all grades make up approximately 33 percent of the student body.

For the 2025–26 academic year, tuition and fees total $68,480 for all grades. Its sister schools are the all-girls Brearley School, the all-girls Chapin School and the all-boys Collegiate School, all in New York City. Forbes magazine ranked Spence ninth on its "America's Best Prep Schools" list in 2010.