Methodist Boys' School is an all-boys secondary school in George Town, Penang, Malaysia. It is one of the two secondary schools in George Town that were established by Methodists, the other being Methodist Girls' School.

Methodist Boys' School was founded in 1891 by a Methodist missionary, Rev. Benjamin H. Balderstone as the Anglo-Chinese School. This secondary school was only renamed Methodist Boys' School in the 1950s when the current school buildings at Air Itam Road were completed. While the school has been an all-boys school since its establishment, girls are now admitted for Form 6 as well.

Pykett Methodist Primary School in George Town also shares its origins with Methodist Boys' School; the primary school was formed at Pykett Avenue after the relocation of the secondary school to Air Itam Road. However, the primary school shut down in 2019 after years of dwindling intake.