Wesley College, informally known as Wesley, is an independent, day and boarding school for boys and girls (co-ed to Year 6 and boys only Years 7–12), situated in South Perth, a suburb of Perth, Western Australia.

The college is a Uniting Church school, which traces its origins back to 1923 when it was established by members of the Methodist Church which was founded by John Wesley.

Since its foundation, the college has been located on a 19-hectare (47-acre) riverside property, near the banks of the Swan River. The campus consists of a Junior School (Manning House) for Pre-kindergarten to Year 4, a Middle School (Years 5 to 8) and a Senior School (Years 9 to 12), performing arts, sporting grounds and boarding facilities for 150 students.

Wesley College is affiliated with the Junior School Heads Association of Australia (JSHAA), the Australian Boarding Schools' Association (ABSA), the Association of Heads of Independent Schools of Australia (AHISA), the Association of Independent Schools of Western Australia (AISWA), and has been a member of the Public Schools Association (PSA) since 1952.

Wesley's sister school is Penrhos College located in Como.