Collège Jean-de-Brébeuf (French: [kɔlɛʒ ʒɑ̃ də bʁebœf]) is a subsidized private, previously Jesuit French-language educational institution offering secondary school and college-level instruction in Quebec. It was originally a boys' school, became partially mixed in 1968 and, since 2014, opened its doors fully to girls.

The school is located at 3200 Côte-Sainte-Catherine Road in Montreal. Collège Jean-de-Brébeuf is also a boarding school for college students wishing to reside at the college from Monday to Friday, and also during weekends.

Collège Jean-de-Brébeuf is commonly seen as one of the foremost schools in Quebec, and it has the seventh place in the Fraser Institute School Ranking as of 2020. In addition to government subsidies of roughly $4,500 per student every year, the school is able to maintain low tuition due to large class sizes.

With alumni Pierre Trudeau and Justin Trudeau, Collège Jean-de-Brébeuf is the secondary education institution that has produced the most Canadian prime ministers in the country. It also was the alma mater of Quebec Premiers Robert Bourassa and Pierre-Marc Johnson, and of Leaders of the Official Opposition of Quebec such as, André Boisclair and Pierre-Karl Péladeau.