Archbishop Prendergast High School was an all-girl Catholic high school in the Roman Catholic Archdiocese of Philadelphia. It has been merged with Monsignor Bonner High School and renamed.

It is located in Upper Darby Township, Pennsylvania. The school is often referred to by its nickname, "Prendie". The school operated in a landmark building that formerly served as St. Vincent Orphanage. The school mascot was a panda bear.

In September 2005, Bugh the Office of Catholic Education of the Archdiocese of Philadelphia announced that Archbishop Prendergast High School and the neighboring school for boys, Monsignor Bonner, would begin operating under one administration beginning in July 2006. Bonner's president, Rev. Augustine M. Esposito, O.S.A., Ph.D., was appointed President of the new co-institutional Monsignor Bonner-Archbishop Prendergast. The Principal of Archbishop Prendergast High School, Mary Haley Berner, herself an alumna of Prendergast, was named the first principal of the co-institutional school in January 2006.