Archbishop Ryan High School is a Roman Catholic high school located in Philadelphia, Pennsylvania. Its namesake is Patrick John Ryan, who served as the second Archbishop of Philadelphia from 1884 to 1911.

Established in 1966, Archbishop Ryan High School is the largest Catholic secondary school in the city of Philadelphia, with a current enrollment of 848 students as of the 2023–2024 school year. Its students come from over 60 Catholic, public, and charter elementary schools located throughout Philadelphia, Bucks, and Montgomery Counties.