Cheltenham High School is a public high school in the Wyncote neighborhood of Cheltenham Township, in the U.S. state of Pennsylvania, located 0.5 miles (800 m) from the border of the city of Philadelphia and 12 miles (19 km) from Center City. Serving grades 9 through 12, Cheltenham is the only high school in the School District of Cheltenham Township. It is fed by Cedarbrook Middle School, the only school in the school district for grades 7 and 8.

In 2017–18 the student ethnicity was distributed as follows: 54% Black, 31% White, 8% Asian, and 5% Hispanic. The school has approximately 1400 students in grades 9 through 12, with a student-teacher ratio of about 12:1.

Cheltenham's athletic teams are known as the Cheltenham Panthers and are members of the PIAA District 1 in the American Conference of the Suburban One League. They have a long-standing tradition of holding a Thanksgiving Day football game against their cross-town rival, Abington Senior High School. The rivalry celebrated its 100th year in 2015.