Doherty Memorial High School is a public high school located in Worcester, Massachusetts, United States. It opened its doors in the fall of 1966, replacing two closing schools: Worcester Classical High School and Worcester Commerce High School.

The school was named for Dr. Leo T. Doherty, an educator, who, over a period of forty years, served Worcester as a teacher, art director, assistant superintendent, and superintendent of schools.

The school has about 1,400 students in grades 9 to 12 in the Worcester Public Schools district. The school's principal is John Staley. The school offers 24 AP courses, with more available through Virtual High School. The school serves the west side (Pleasant & Chandler Street, Tatnuck Square, Salisbury Street, Forest Grove, Newton Square, and June, Mill, Pleasant, and May Streets neighborhoods) of Worcester.

The original building was demolished in June 2024. A new, 425,000-square-foot facility opened in August 2024. The site of the former high school will be used for parking lots and an athletic complex.