Helix High School, or Helix Charter High School, is a charter high school in La Mesa, California, built in 1952. It received its charter in 1998. Helix is part of Grossmont Union High School District, and serves a mid-level socioeconomic community. It has a student body of approximately 2,400 students. Helix serves parts of La Mesa, Lemon Grove, and Spring Valley; however, as a charter school, all high school students in the state of California are eligible to attend.

Helix High School is accredited by the Western Association of Schools and Colleges (WASC) and was named a California Distinguished School in 2001 and 2009.