Nipmuc Regional High School

Nipmuc Regional High School is a public high school in Upton, Massachusetts, United States, part of the Mendon-Upton Regional School District.

Nipmuc Regional High School is located on a fifty-acre wooded lot in Upton, Massachusetts, in the Blackstone Valley region of the state. It serves the towns of Mendon and Upton through a cooperative arrangement established in 1961. The school was named after the Nipmuc indigenous people of the area. In addition to Nipmuc Regional, there are three other schools in the Mendon-Upton Regional School District: Miscoe Hill Middle School, Clough Elementary School (Mendon), and Memorial Elementary School (Upton). In 2024, the year-round populations of the two towns were 6,228 (Mendon) and 8,000 (Upton).