Notre Dame High School (Cape Girardeau, Missouri)

Notre Dame Regional High School is a private Roman Catholic high school located in Cape Girardeau, Missouri. The school enrolls students in grades 9–12, and belongs to the Diocese of Springfield-Cape Girardeau.

Notre Dame serves students from several communities in southeast Missouri and southern Illinois. Notre Dame has also served as host to several international students, including students from Japan, China, Indonesia, South Korea, Thailand, Mexico, Spain, Brazil, and the Philippines.