Notre Dame High School for Girls was a private, Roman Catholic, all-girls, college prep 9-12 high school in Chicago, Illinois, United States. It was founded in 1938 by the Sisters of Notre Dame de Namur and in 2009, was incorporated by the Archdiocese of Chicago, making it part of the St. Ferdinand Parish. Its teachings were based on the educational philosophy of St. Julie Billiart, founder of the Sisters of Notre Dame de Namur. The school provided moral, academic, physical and social education.

On June 16, 2016, the Roman Catholic Archdiocese of Chicago announced that, after years of dwindling enrollment, the school would be closing its doors on July 1, 2016.