Patrick Henry High School is a four-year public high school in San Diego, California, United States. It is part of San Diego Unified School District. It is attended by students residing in Del Cerro, San Carlos, Allied Gardens, Mission Valley and the College Area.

Patrick Henry High School is accredited by the Western Association of Schools and Colleges. The 57-acre (230,000 m²) campus includes a counseling center, child development center, computer and science labs, a cafetorium, library and a performing arts theater. The mascot of Patrick Henry High School is the Patriot, a reference to Patrick Henry, an American Founding Father.

Patrick Henry High School participates in the Voluntary Ethnic Enrollment Program (VEEP) whereby approximately 600 students travel daily from an underrepresented minority community and are regularly enrolled, full-time students. In 2020, the ethnic composition of the school represented more than 20 ethnic groups, Patrick Henry High School is approximately 39.4% White, 29.8% Hispanic, 15.7% Asian, 8.7% Biracial, 5.8% Black, 0.3% Pacific Islander, 0.2% Not specified, and 0.1% Native American.