St. Lucie West Centennial High School is a public high school in Port St. Lucie, Florida, United States, serving students in ninth through twelfth grades.

As of the 2014–15 school year, the school had an enrollment of 2,502 students and 125.0 classroom teachers (on an FTE basis), for a student–teacher ratio of 20.0:1. There were 1,181 students (47.2% of enrollment) eligible for free lunch and 171 (6.8% of students) eligible for reduced-cost lunch.