The UCLA College of Letters and Science (or simply UCLA College) is the arts and sciences college of the University of California, Los Angeles (UCLA). It encompasses the Life and Physical Sciences, Humanities, Social Sciences, Honors Program and other programs for both undergraduate and graduate students. It is often called UCLA College or the College, which is not ambiguous because the College is the only educational unit at UCLA to be currently denominated as a "college." All other educational units at UCLA are currently labeled as schools or institutes.

The College is the largest academic unit at UCLA and the largest in the entire UC system. The bulk of UCLA's student body belongs to the College, which includes 50 academic departments, 99 majors, 25,000 undergraduate students, 2,700 graduate students and 900 faculty members. Virtually all of the academic programs in the College are ranked very highly and 11 were ranked in the top ten nationally by the National Research Council.