University High School (also known as UHS or "Uni") is one of six public high schools serving grades 9-12 in the city of Irvine, California, United States. It was established in 1970 and is situated on 55 acres (22 ha) of land in the southwestern portion of the city, adjacent to the University of California, Irvine (UCI).

The school comprises six main academic buildings, a performing arts theater, a band room for instrumental music, a swimming pool, eight tennis courts, an indoor gymnasium supplemented with other indoor athletic facilities, a stadium, and several practice fields. Housed within the facilities are the departments of English, world languages, math, science, social science, instrumental music, art, industrial technology, athletics, physical education, English proficiency programs, special education, and the Orange County Deaf and Hard of Hearing Program. The school colors are navy blue, Columbia blue, and white. The school mascot is Tommy the Trojan.

University High School was named the best public high school in California and 8th best public high school in America in 2011 by Newsweek. University was also the highest ranked institution on the list that was not a charter or magnet school.