Wayzata High School is a comprehensive public high school in Plymouth, Minnesota, United States, a suburb of Minneapolis. The high school, operated by Wayzata Public Schools, had about 3711 students in grades 9 to 12 as of 10/1/23, making it Minnesota's largest secondary school by enrollment. It is also Minnesota's largest secondary school by size, with an interior of 658,000 square feet (61,100 m²). The district boundaries include all or part of eight municipalities: Corcoran, Maple Grove, Medicine Lake, Medina, Minnetonka, Orono, Plymouth, and Wayzata. The school finished an expansion project in 2017 with the new capacity of 3,900. It is part of the Lake Conference. Scott Gengler is the principal.

In 2015, Newsweek ranked the school 150th on its "List of the 500 Top High Schools in America". U.S. News & World Report ranked the school 432nd among 21,000 schools nationally and 6th in Minnesota in 2021.