Phillis Wheatley High School is a secondary school located at 4801 Providence Street in Houston, Texas, United States with a ZIP code of 77020. Wheatley is a part of the Houston Independent School District. Wheatley, named after Phillis Wheatley, is located inside the 610 Loop in the Fifth Ward.

Wheatley has a technology magnet program inherited from the closure of Middle College for Technology Careers in spring 2006; Wheatley's program began in fall 2006.

In 1979, Wheatley principal Charles Herbert said that "For many, Fifth Ward is Wheatley High School" and that African-Americans who grew up in the Fifth Ward "still cling closely to Wheatley" even after they had moved to other parts of the United States.