Williamsville East High School is one of the three high schools located in the Williamsville Central School District in Williamsville, New York. The other two high schools in the district are Williamsville North High School and Williamsville South High School. For the 2016–2017 school year, 1,030 students were enrolled in the school, about the same as the 2004–2005 school year, where 1,048 students were enrolled. In the 2024-2025 school year, the school reported an enrollment of 940 students.