Wylie Independent School District (Collin County, Texas)

Wylie Independent School District is a school district based in Wylie, Texas, United States and covers much of south central Collin County.

Wylie ISD serves most of the city of Wylie, the city of St. Paul, portions of the cities of Lucas and Murphy, the Collin County portion of the city of Sachse, and much of Seis Lagos. Some areas in the Dallas city limits lie in the Wylie ISD limits. As of 2023 enrollment has grown to just over 19,000 students. The average student to teacher ratio is 17:1.

In 2025, the school district was rated with an "A" by the Texas Education Agency.