The University of Portland (UP) is a private Catholic university in Portland, Oregon, United States. It was founded in 1901 and is affiliated with the Congregation of Holy Cross, which also founded UP's sister school, the University of Notre Dame. UP enrolls approximately 3,700 students.

The campus is in the University Park neighborhood near St. Johns, on a bluff overlooking the Willamette River. With a college of arts and sciences, a graduate school, and schools of business, education, engineering, and nursing and health innovations, it is Oregon's only comprehensive Catholic university. UP is North Portland's largest corporation and has an annual economic impact on Portland of $170 million. More than 17,000 alumni live in the Portland metropolitan area.