The Colegio de San Juan de Letran (transl. College of San Juan de Letran), also referred to by its acronym CSJL, is a private Catholic coeducational basic and higher education institution owned and run by the friars of the Order of Preachers in Intramuros, Manila, Philippines. It was founded in 1620. Colegio de San Juan de Letran has the distinction of being the oldest college in the Philippines and the oldest secondary institution in Asia.

The Colegio was given Level III accreditation by the Philippine Accrediting Association of Schools, Colleges and Universities in the Basic Education department, College of Liberal Arts and Sciences (CLAS), and College of Business Administration and Accountancy (CBAA).

Letran remains in its original campus in Intramuros, Manila, and is a member of the Intramuros Consortium. It is a long-time member of the National Collegiate Athletic Association.