The University of the Philippines Manila (UPM; Filipino: Unibersidad ng Pilipinas Maynila) is a public research university located in Ermita, Manila, Philippines. It is the oldest of eight constituent universities of the University of the Philippines System, and predates the founding of UP by three years. It was originally established on December 1, 1905, as the Philippine Medical School and later renamed as the UP College of Medicine and Surgery on June 10, 1907. In 1983 it was renamed as University of the Philippines Manila.

UP Manila administers and operates the Philippine General Hospital, the largest medical center and the national referral center for health in the Philippines. The university is the home of the National Institutes of Health. This section led early testing for COVID-19. It continues to conduct health research in various fields.

Its 14-hectare campus occupies two large city blocks. The campus contains pre-war heritage buildings and structures built during the American Period and designed by American architect William E. Parsons. These were declared to be historical landmarks by the National Historical Commission of the Philippines.

Since 2001, the College of Medicine and the College of Nursing have been recognized as Centers of Excellence by the Commission on Higher Education.