Notre Dame High School is a coeducational Roman Catholic college preparatory school in the Lawrenceville section of Lawrence Township, in Mercer County, in the U.S. state of New Jersey. The school operates under the supervision of the Catholic Diocese of Trenton and has been accredited by Cognia since 2013.

As of the 2023–24 school year, the school had an enrollment of 894 students and 67.8 classroom teachers (on an FTE basis), for a student–teacher ratio of 13.2:1. The school's student body was 77.6% (694) White, 5.6% (50) Black, 5.0% (45) two or more races, 4.6% (41) Asian, 6.7% (41) Hispanic and 0.4% (4) American Indian / Alaska Native.