Trenton Central High School is a three-year comprehensive public high school that serves students in tenth through twelfth grades from Trenton, in Mercer County, in the U.S. state of New Jersey, operating as part of the Trenton Public Schools.

As of the 2023–24 school year, the school had an enrollment of 2,138 students and 154.9 classroom teachers (on an FTE basis), for a student–teacher ratio of 13.8:1. There were 809 students (37.8% of enrollment) eligible for free lunch and 20 (0.9% of students) eligible for reduced-cost lunch.