Loyola University Chicago (Loyola or LUC) is a private Jesuit research university in Chicago, Illinois, United States. Founded in 1870 by the Society of Jesus, Loyola is one of the largest Catholic universities in the United States. Its namesake is Saint Ignatius of Loyola. Loyola's professional schools include programs in medicine, nursing, and health sciences anchored by the Loyola University Medical Center, and the Loyola University Chicago School of Law. It is classified among "R1: Doctoral Universities – Very high research spending and doctorate production".

Comprising thirteen colleges and schools, Loyola offers more than 80 undergraduate and 140 graduate/professional programs and enrolls approximately 17,000 students. Loyola has five campuses across the Chicago metropolitan area, as well as a campus in Rome. Another guest program in Beijing was closed in 2018. The flagship Lake Shore Campus is on the shores of Lake Michigan in the Rogers Park and Edgewater neighborhoods of Chicago, just over seven miles (11.3 km) north of the Loop.

Loyola's athletic teams, nicknamed the Ramblers, compete in NCAA Division I as members of the Atlantic 10 Conference. Loyola won the 1963 NCAA men's basketball championship and remains the only school from Illinois to do so. The Ramblers are also two-time (2014, 2015) NCAA champions in men's volleyball.